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Citrulline

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Product Range Citrulline200 Citrulline1000
Pack Size 30 x 4g ℮ 30 x 4g ℮
Ingredients Maltodextrin, L-citrulline. Maltodextrin, L-citrulline.


Description
Indication

Clinical Use

Urea Cycle Disorders1 (UCD)


UCD is an umbrella term encompassing six genetic disorders of protein metabolism, all of which result in impairment of the body’s ability to remove waste nitrogen. UCD can have acute, chronic and intermittent clinical manifestations occurring at any age. Their clinical hallmark is the hyperammonaemia crisis.


Due to impaired synthesis, L-arginine becomes an essential amino acid in all of the UCDs, with the exception of Arginase 1 deficiency. It must therefore be supplemented as either L-arginine or its precursor, L-citrulline. In some of the UCDs, low plasma levels of L-citrulline are found. Supplementing the diet with L-citrulline will help manage both low L-citrulline and low L-arginine levels.


Preparation Guidelines

To be determined by the clinician or dietitian. Suggested methods include:

1. Measure out 100ml of water into a shaker.
2. Add one sachet.
3. SHAKE vigorously for 30 seconds.
For Citrulline200, wait 5 minutes*, shake again and serve.
For Citrulline1000, wait 10 minutes*, shake again and serve.
(*Waiting times will enhance dispersion of the powder in the water.)




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1. Pour the liquid protein substitute into a shaker.
2. Add in the SDAA.
3. Shake for 30 seconds.
4. Serve.




1. Mix the dry SDAA and protein substitute powders together.
2. Follow the protein substitute preparation instructions. You may wish to use extra water.
3. Serve.




Combinations

Citrulline200, Citrulline1000 can be used in conjunction with other Vitaflo products for the dietary management of UCD:

Further Reading


1. Häberle J, Burlina A, Chakrapani A, Dixon M, Karall D, Lindner M et al. Suggested guidelines for the diagnosis and management of urea cycle disorders: First revision. Journal of Inherited Metabolic Disease. 2019:42 (6); 1192-1230. DOI:10.1002/jimd.12100.


Citulline200 and Citrulline1000 are Food for Special Medical Purposes for the dietary management of inborn errors of metabolism. For use under medical supervision. For healthcare professional use only.