POOLED ANALYSIS METHODOLOGY
The pooled analysis comprised 170 infants (about 3 months old) who were initially given a CoMiSSTM score of 12 or higher, and who scored below 12 (average 5) after one month on an hypoallergenic specialty formula. The analysis showed that these infants had a 75% likelihood for a positive food challenge test undertaken with cows’ milk protein when CoMiSSTM was re-scored. Non-IgE mediated CMA cannot be diagnosed by blood test and the food challenge test – which requires an elimination diet (excluding milk proteins) to be implemented – is currently the gold standard for CMA diagnosis, however it is not always performed.
Professor Yvan Vandenplas from the UZ Brussel’s Department of Pediatrics in Belgium was the leading author of the just published paper and one of the experts behind the CoMiSSTM tool. He said: ”The pooled data across three studies supports the value of CoMiSSTM as an awareness tool for CMA, as does the feedback from healthcare professionals who use it. With CoMiSSTM, primary healthcare clinicians now have an easy and fast scoring system to assess the likelihood of CMA. Symptomatic children who score 12 or higher on the CoMiSSTM score can be considered for alternative nutritional approaches much earlier in life.”
A prospective validation study is currently ongoing. CoMiSSTM is available through Nestlé Health Science in hard copy, can be downloaded from the web or completed on-line.
Developed by top international experts, CoMiSSTM (Cows’ Milk-related Symptom Score), is a fast and easy-to-use awareness tool that can aid an earlier accurate diagnosis.
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