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PKU sphere | glycomacropeptide (GMP)

PKU sphere™ | Glycomacropeptide (GMP)

A powdered protein substitute for the dietary management of Phenylketonuria. PKU sphere is Vitaflo’s first glycomacropeptide (GMP) based protein substitute and is suitable from 4 years of age. PKU sphere has a GMP-dominant protein source supplemented with amino acids, bringing patients the potential benefits of GMP without any compromise in nutritional profile. PKU sphere can easily be made to an individual’s preferred volume.
Download the PKU sphere datacard

PKU sphere is a food for special medical purposes and must be used under medical supervision.

What is GMP?

Glycomacropeptide (GMP) is a protein naturally low in phenylalanine. Protein substitutes based on GMP are regularly perceived to be more palatable than those based on amino acids1,2. Palatability of protein substitutes is key to compliance,3 making GMP an ideal alternative protein source for Phenylketonuria (PKU).

  1. Van Calcar, SC. et al. Improved nutritional management of phenylketonuria by using a diet containing glycomacropeptide compared with amino acids.
  2. Daly, A. et al. SSIEM abstract 2016: Impact of the amino acid profile of casein glycomacropeptide on metabolic control in children in PKU. 2016 Am J Clin Nutr. 2009; 89 (4): 1068 – 77
  3. Giovannini, M., et al. Phenylketonuria: nutritional advances and challenges. Nutr Metab (London) 2012
Key Features of PKU sphere:
  • Available in 15g and 20g PE pre-measured sachets.
  • Contains a full range of micronutrients and DHA.
  • Each 15g PE sachet contains 28mg Phe and 20g PE sachet contains 36mg Phe.
  • Pack sizes are available in either Red berry, Vanilla or Chocolate flavour.
  • Contains just 91 calories and 1.7g sugar per 15g PE sachet. Contains just 120 calories and 2.2g of sugar per 20g PE sachet.
Preparation Guidelines

PKU sphere15 PKU sphere20

1. Pour 100ml of water into shaker.

1. Pour 120ml/4oz of water into shaker.

2. Add one sachet of PKU sphere15 to shaker.

2. Add one sachet of PKU sphere20 to shaker.

3. Shake well.

3. Shake well.

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Our healthcare professional resources for PKU

Use of PKU sphere as a protein substitute during preconception for a patient with Hyperphenylalaninemia

Melanie Hill, Specialist Dietitian for Adults with Inherited Metabolic Diseases, Sheffield Teaching Hospitals NHS Foundation Trust

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Online resource for PKU patients

Inborn Errors of Metabolism