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Cows' Milk Protein Allergy

Nestlé Health Science: Supporting CMA diagnosis and management

Cows' milk allergy (CMA), also known as cows' milk protein allergy (CMPA), is one of the most common food allergies in infants and it typically presents with diverse and non-specific symptoms, often making it challenging to diagnose.1 At Nestlé Health Science, we understand this challenge and are committed to providing leading expert-developed tools, nutritional solutions and support to help healthcare professionals facilitate earlier diagnosis and appropriate management of infants and young children with CMA. We are also dedicated to providing information, tools and support for caregivers to help raise awareness around the symptoms of CMA.

Signs and symptoms

Inconsolable crying, colic, skin rashes, vomiting, diarrhoea, and constipation are all common signs and symptoms of CMA, especially in early infancy.

Signs & symptoms
The CoMiSS® awareness tool is available in print and online

Consider CMA

Leading experts have developed the Cows' Milk-related Symptom Score (CoMiSSTM) to help healthcare professionals recognise and assess non-specific signs and symptoms that could be indicative of CMA.

CoMiSS® tool
Doctor examining an infant with suspected cow’s milk protein allergy

Clarify the diagnosis

Diagnosing CMA can often be challenging, and tests are available to help assess the presence of IgE CMA. In non-IgE CMA, the quality standard for diagnosing it is the elimination diet, which is a diet free from cows' milk protein, followed by a food challenge.2

Diagnosing CMA


The Nestlé Health Science range of hypoallergenic nutritional solutions, Althéra and Alfamino, are tailor-made to meet the specific nutritional needs of infants with CMA.
Nestlé Health Science’s

commitment to CMA education

Nestlé Health Science is dedicated to developing and sharing leading scientific information and educational tools to support in the identification of CMA for healthcare professionals and to help caregivers during their journey with CMA.

Prof. Yvan Vandenplas talks about how to diagnose CMPA

Expert Corner: CMA Diagnosis

Leading experts in paediatric gastroenterology and food allergy answer common questions related to the diagnosis of CMA in our online video series.

Watch now
Infant sleeping

Case studies


Understand some of the diagnostic and management challenges – from the initial symptom presentation to diagnosis followed by the dietary management in a series of case studies.

Read more
Mother searching for information online while baby sleeps

Support for parents and caregivers

Information and tools are available for parents to support them along their CMA journey.

Find materials


  1. Koletzko S, et al. Diagnostic Approach and Management of Cow’s-Milk Protein Allergy in Infants and Children: ESPGHAN Gl Committee Practical Guidelines. JPGN 2012;55:221–9
  2. NICE. Food Allergy NICE (QS118). 2016.
IMPORTANT NOTICE: Mothers should be encouraged to continue breastfeeding even when their babies have cows' milk protein allergy. This usually requires qualified dietary counselling to completely exclude all sources of cows' milk protein from the mothers’ diet. If a decision to use a special formula intended for infants is taken, it is important to follow the instructions on the label. Unboiled water, unboiled bottles or incorrect dilution can make babies ill. Incorrect storage, handling, preparation and feeding can eventually lead to adverse effects on the health of babies. Formula for special medical purposes intended for infants must be used under medical supervision.